Mechanism of action and treatment recommendations of Osimertinib

Mechanism of action and treatment recommendations of Osimertinib

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Article by Pharmacist Ly Anh Thu - Clinical Pharmacist - Pharmacy Department - Vinmec Central Park International General Hospital

Osimertinib is a drug that is mainly used in the treatment of lung cancer. In order for the drug to be effective, patients need to clearly understand the information about the drug as well as the dosage and how to use it.

1. Composition and content of Osimert 80 mg (Osimertinib)
In terms of ingredients and content, Osimertinib includes:

Tagrisso tablets 40mg
One tablet contains 47.7 mg osimertinib mesylate equivalent to osimertinib
Tagrisso tablets 80mg
One tablet contains 95.4 mg osimertinib mesylate equivalent to 80 mg osimertinib
Including other excipients.
2. Mechanism of action of Osimertinib
Osimertinib is a tyrosine kinase inhibitor (TKI). It is an irreversible inhibitor of the Epidermal Growth Factor Receptor (EGFR) with sensitive mutations (EGFRm) and the T790M mutation that is resistant to TKIs. The drug therefore inhibits the proliferation, growth, and metastasis ofcancer cellsand help respond to chemotherapy,radiotherapy. Tagrisso acts on T790M and may slow or stop the disease.lung cancerprogression. Medications may help shrink tumors.

3. What diseases does the drug treat?
Tagrisso contains the active ingredient osimertinib, which belongs to the protein kinase inhibitor group of anticancer drugs. Therefore, the drug is used to treat adult patients with non-small cell lung cancer. The drug is used when:

The test result was positive for the “T790M” mutation.
The patient's cancer progressed or worsened despite previous treatment, which may include drugs that work by inhibiting “EGFR” (epidermal growth factor receptor).

Tagrisso contains the active ingredient osimertinib which can cause side effects in patients.
Tagrisso contains the active ingredient osimertinib which can cause side effects in patients.
4. How should I take the medicine and what is the dosage?
As for dosage, the recommended dose is one 80mg tablet per day. Your doctor may reduce the dose to one 40mg tablet per day if needed.

Directions for use: Patients should swallow the tablet whole with a little water. Do not crush, break or chew the tablet. Take Tagrisso at the same time each day. The medicine can be taken with or without food. In case the patient has difficulty swallowing the tablet whole, the medicine can be dissolved in water by:

Put the tablet in a glass, add 50ml (about 2/3 glass of water), do not use any other liquid, especially carbonated water. This medicine will not dissolve completely, so you just need to stir until the tablet is broken into very small pieces. Drink this solution immediately after dissolving.
To ensure that the patient has taken all the medicine, rinse the cup with 50ml of water and then continue drinking. In case the patient takes the medicine through a gastric tube, dissolve the medicine in 15ml of filtered water, draw it into the syringe, then add another 15ml to the cup to rinse the cup and draw it into the syringe. Inject 30ml of medicine through the tube, then use another 30ml of filtered water to rinse the tube.

5. When should Osimertinib not be used?
In the following cases, patients should not use Osimertinib or should consult a doctor or pharmacist before using it.

Patients who are allergic (hypersensitive) to Osimertinib or any ingredient of the drug.
The patient is taking St. John's Wort (Hypericum perforatum).
6. Undesirable side effects of Osimertinib
Common side effects patients experience while using Osimertinib

Diarrhea
Skin and nail problems, signs may include itching, dry skin, rashes, redness around the nails. Using moisturizing products on the skin and nails will help to resolve these symptoms.
Gastritis, inflammation of the lining of the mouth.
Decreased white blood cell count.
Decreased platelet count in the blood.
Please notify your doctor immediately if you detect the following serious side effects:

Sudden difficulty breathing with cough or fever, may be a sign ofpneumonia. Your doctor may tell you to stop using Tagrisso if you experience this side effect.
If the patient experiences watery eyes, sensitivity to light,eyesore, red eyes or changes in vision.

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